On December 7-9, 2018, the VI Scientific Practical Conference “A Systematic Approach to Pain Treatment. Topical Issues of Regional Anesthesia ”, which was organized jointly with the Moscow Scientific Society of Anesthesiologists and Resuscitators. More than 200 specialists from various regions of Russia took part in the conference. This year, the conference was held in the form of discussion panels with arguments “for” and “against” on issues of opioid free anesthesia, conducting neuroaxial blockades and blockages of peripheral nerves in adult patients and children. Traditionally, the program of the event included lectures on topical issues and new directions in the field of pain treatment, patient safety, prevention and treatment of complications associated with anesthesia.